Over the last few decades, Dr. Colloca has conducted studies on the behavioral, neural, and pharmacological mechanisms of pain modulation related to placebo and nocebo effects. Her lab has also developed an interest in virtual reality as a non-pharmacological approach to relieve pain and other symptoms. She has published in top-ranked international journals including Biological Psychiatry, Pain, Nature Neuroscience, JAMA, Lancet Neurology, Science and NEJM. As a result, Dr. Colloca has developed an international reputation as a leading scientist in advancing knowledge of the neurobiological mechanisms of descending pain modulation and placebo and nocebo effects with an integrative approach that includes psychopharmacological, neurobiological, and behavioral approaches.